Effective therapy for AML with RUNX1 mutation by cotreatment …
WEBFeb 10, 2022 · The majority of RUNX1 mutations in acute myeloid leukemia (AML) are missense or deletion-truncation and behave as loss-of-function mutations. Following standard therapy, AML patients expressing mtRUNX1 exhibit inferior clinical outcome than those without mutant RUNX1.
RUNX1 mutations in acute myeloid leukemia are associated with …
WEBMay 3, 2016 · We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid leukemia...
RUNX1 mutations in acute myeloid leukemia are associated with ... - PubMed
WEBWe evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid leukemia (AML).
Role of RUNX1 in hematological malignancies
WEBApr 13, 2017 · Somatic mutations and chromosomal rearrangements involving RUNX1 are frequently observed in myelodysplastic syndrome and leukemias of myeloid and lymphoid lineages, that is, acute myeloid leukemia, acute lymphoblastic leukemia, and chronic myelomonocytic leukemia.
RUNX1 Mutations in Acute Myeloid Leukemia: Results From a …
WEBFeb 22, 2011 · RUNX1 mutations predicted for resistance to chemotherapy (rates of refractory disease 30% and 19%, P = .047, for RUNX1 -mutated and wild-type patients, respectively), as well as inferior event-free survival (EFS; P < .0001), relapse-free survival (RFS, P = .022), and overall survival (P = .051).
The Clinical, Molecular, and Mechanistic Basis of RUNX1 …
WEBFeb 2, 2020 · RUNX1 plays an important role in the regulation of normal hematopoiesis. RUNX1 mutations are frequently found and have been intensively studied in hematological malignancies. Germline mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML).
Targeting RUNX1 in acute myeloid leukemia: preclinical
WEBRUNX1 forms a heterodimeric complex with CBFB. Germline mutations and somatic alterations (i.e. translocations, mutations and abnormal expression) are frequently associated with acute myeloid leukemia (AML) with RUNX1 mutations conferring unfavorable prognosis.
Multiomic single cell sequencing identifies stemlike nature of …
WEB4 days ago · Silva, F. P. et al. Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status. Blood 114 , 3001–7 (2009).
Identification of Key Genes and Pathways Associated with RUNX1 ...
WEBOct 5, 2018 · Mutations of RUNX1 gene can lead to acute leukemia and affect the prognosis of AML patients. We aimed to identify pivotal genes and pathways involved in RUNX1-mutated patients of with acute myeloid leukemia (AML) and to explore possible molecular markers for novel therapeutic targets of the disease.
Therapy-Related Myelodysplastic Syndromes and Acute Myeloid Leukemia
WEB1 day ago · Therapy-related myeloid neoplasms including myelodysplastic syndrome and acute myeloid leukemia (t-MDS/AML) occur in patients previously exposed to cytotoxic therapy (chemo or radiation) for a prior malignancy or immunotherapy for autoimmune disorders. ... RUNX1, and IDH2 predicts the risk of myeloid malignancy in …
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